Showing posts with label Cord Blood News. Show all posts
Showing posts with label Cord Blood News. Show all posts

New Mississippi Law: To reduce teen pregnancy with cord-blood law

The law took effect July 1 but hasn't been used yet. Cord blood samples would have to be taken immediately after birth, and the state medical examiner is setting administrative rules for how the blood will be collected and stored.

If a girl younger than 16 gives birth and won't name the father, a new Mississippi law says authorities must collect umbilical cord blood and run DNA tests to prove paternity as a step toward prosecuting statutory rape cases.

The new law says it's reasonable to think a sex crime has been committed against a minor if the baby's mother won't identify the father or lists him as unknown, or if the identified father disputes paternity, is 21 or older, or is deceased. The law says health care workers and facilities cannot face civil or criminal penalties for collecting cord blood, and failure to collect is a misdemeanor offense. The law doesn't address whether the mother can refuse blood collection or what would happen to her if she does.
The DNA tests could lead to prosecution of grown men who have sex with underage girls, said Republican Gov. Phil Bryant.

Bryant's staff says the idea for the law came from public meetings conducted by the governor's teen pregnancy prevention task force — a group that focuses mostly on promoting abstinence.

Megan Comlossy, health policy associate for the National Conference of State Legislatures, said she thinks Mississippi is the first state to enact a law authorizing the collection of blood from the umbilical cord — a painless procedure — to determine paternity.

Supporters say the law is intended to chip away at Mississippi's teen pregnancy rate, which has long been one of the highest in the nation. But critics say that though the procedure is painless, it invades the medical privacy of the mother, father and baby. And questions abound: At roughly $1,000 a pop, who will pay for the DNA tests in the country's poorest state? Even after test results arrive, can prosecutors compel a potential father to submit his own DNA and possibly implicate himself in a crime? How long will the state keep the DNA on file?


But Bear Atwood, legal director for the American Civil Liberties Union of Mississippi, said it's an invasion of privacy to collect cord blood without consent of the mother, father and baby. She also said that an underage girl who doesn't want to reveal the identity of her baby's father might skip prenatal care: "Will she decide not to have the baby in a hospital where she can have a safe, happy, healthy delivery?"

Source: http://www.usatoday.com/
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Toxins found in umbilical cord blood of newborns


Credit: http://environmentaldefence.ca
According to a report, Detectable levels of a large number of environmental chemicals have been found in the cord blood of some newborns, raising concerns that Canadian children already carry toxins in their bodies at birth. The report was released on Wednesday by Environmental Defense.

Some of the chemicals tested for are linked to serious health conditions such as cancer, and developmental and reproductive problems.

Environmental Defence tested the umbilical cord blood of three anonymous newborns in Toronto and Hamilton, finding a total of 137 chemicals overall. The number of toxins in each baby's cord blood ranged from 55 to 121.
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Many of the chemicals are linked to serious health conditions: 132 are reported to cause cancer in humans or animals; 110 are considered toxic to the brain and nervous system; and 133 cause developmental and reproductive problems in mammals.

Toxins that were found in the babies’ umbilical cords study were flame retardants, lead, organochlorine pesticides and perfluorochemical (PFCs), a chemical found in non-stick cookware, stain-resistant carpets and fabrics, coatings on some food packaging such as microwave popcorn bags, and fast food wrappers.

In addition, some banned chemicals were also detected in the study’s findings, suggesting that toxic chemical can persist in our bodies and in the environment for years.

The group expressed concern that their findings indicated that infants are exposed to chemicals in the womb because of the widespread pervasiveness of these pollutants in the environment and in consumer goods.

Environmental groups have been asking the federal government to take actions to ensure that toxic chemicals are not used in industry or products.

In response to the study, Douglas Haines, director of Health Canada’s Chemicals Surveillance Bureau, said it was too early to conclude how bad the exposure is on the human body.
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The report, Pre-Polluted: A Report on Toxic Substances in the Umbilical Cord Blood of Canadian Newborns, can be downloaded at www.environmentaldefence.ca

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FDA Approves stem sell product "DUCORD" from Duke

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FDA Approves stem sell product "DUCORD" from Duke


Duke University School of Medicine has received approval from the Food and Drug Administration to market stem cell product, called DUCORD for use in hematopoietic stem cell transplantation for patients with disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment.

Hematopoietic stem cells, derived from cord blood and produced in the bone marrow, are able to renew themselves and differentiate into specialized cells. When transplanted in people with lymphoma, leukemia, immune disorders and genetic conditions, these robust cells can establish a life-saving new blood and immune system.

The approval marks a significant achievement for Duke and the Carolinas Cord Blood Bank (CCBB), a not-for-profit, public cord blood bank at the medical school, which has pioneered cord blood transplants for children and adults with cancer, blood disorders and inherited diseases. Only two other cord blood banks in the United States have received FDA approval to market similar stem cell products.

Blood from babies’ umbilical cords, which was once discarded, is rich in hematopoietic stem cells. Joanne Kurtzberg, M.D., director of Duke’s Pediatric Blood and Marrow Transplant Program, was a trailblazer in their use for transplants and was a founder of the public bank through CCBB. Kurtzberg has remained at the forefront of expanding the use of cord blood for patients with life-threatening diseases.

Prior to receiving the FDA license, CCBB provided more than 1,500 high quality cord blood units throughout the world under an FDA Investigative New Drug application. Currently, all CCBB units are listed on the National Bone Marrow and Donor Program’s “Be the Match” registry, a central database for transplant centers to search and request cord blood units for patients in need of unrelated donors for transplantation.

Reference: http://www.dukehealth.org
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Giuliana and Bill Rancic Decided to Chose to Bank Duke’s Cord Blood

The reality television stars Giuliana and Bill Rancic have written about their decision to privately store their newborn son's umbilical cord blood.

After years of fertility struggles — including unsuccessful attempts at in vitro fertilization and subsequent miscarriage — the couple welcomed Edward Duke via gestational surrogate on Aug. 29.

The Rancics explained that Giuliana's battle with breast cancer and their own struggle with infertility prompted them to prepare for the future.
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The Rancics have partnered with the Cord Blood Registry, a large stem cell bank, to ensure parents become informed about the practice. People notes the Rancics are paid spokespersons for Cord Blood Registry.

Before the birth, the stars of Giuliana & Bill began preparing for their baby boy and were introduced to the benefits of cord blood banking.
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Source: http://www.huffingtonpost.com
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Cord Blood-Derived Stem Cells : New Therapeutic Option for Brain Disorders

Stem cell technology has the potential to revolutionize medicine, but the revolution has been considerably slower than expected. Government restrictions and ethical dilemmas have put up roadblocks to fast-paced biological research, and even when these roadblocks are absent, controlling the behavior of stem cells (cells that have the ability to form a number of cell types and tissues) in a petri dish has proved tricky to say the least.

Progress steady - Cord blood stem cells can be harvested from the umbilical cord and placenta of a newborn baby and stored for future use, the idea being that they can be used down the road should that baby (or a genetically similar relative) become sick. These stem cells have been used to treat close to 100 blood-based conditions, including several types of leukemia.
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One particular challenge has been to force cord blood stem cells to become anything other than a blood cell. This is because stem cells exist in varying degrees of “stemness”; that is they differ in their ability to form different kinds of tissue or cells. For example, blood stem cells are really good at generating all of the different types of blood cells, but do not generate skin cells. However, researchers at the Salk Institute for Biological Studies in collaboration with scientists in Barcelona, Spain, have succeeded in coaxing these stem cells to become neurons, a groundbreaking step in the treatment of traumatic brain injury and other neuronal disorders.

When a stem cell divides, the DNA of one cell retains its stem cell identity. The DNA in the second cell, on the other hand, can assume a different identity. The first step in assuming this identity (known as differentiation) generally involves turning on a master-regulator gene that then controls the activity of another gene and another gene and so on until, for example, the cell becomes a neuron. The key to controlling stem cells, therefore, lies in figuring out how to turn on the master-regulator.

In order to turn cord blood cells into neuronal cells, Alessandra Giorgetti and colleagues first manipulated the cells so that they produced an increased amount of a gene called Sox2. They then cultured the cells and analyzed their genetic behavior. What they found was that these manipulated cells were starting to behave like immature neurons: Sox2 was the master-regulator.

The next challenge was to keep the cells on track so that they finished the job of becoming a neuron. Using special conditions the team managed to get the cells to form mature neurons that both extended long nerve-like projections and responded to electrical stimulation in vitro.

The real test, however, was whether or not these cells repopulate a damaged brain. It is one thing to generate a single cell type, and quite another to induce those cells to form a coherent and functional tissue. Giorgetti and her colleagues therefore took the cord blood-derived neuronal cells and transplanted them into immuno-compromised mice (that could not reject the non-mouse graft) and monitored their progress over a period of three months. They found that indeed the cord blood-derived neurons grew and integrated into the mouse brains, and were capable of limited activity.

While it maybe some time before such a treatment reaches the clinic, this work emphasizes the potential of this type of stem cell. With cord blood banking becoming more and more commonplace, and an expansion of the application of cord blood stem cells beyond the treatment of blood disorders, these malleable cells are fast becoming the stars of stem cell research.

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New England Cord Blood Bank Using Sepax 2 from Biosafe as their Cord Blood Processing Platform

New England Cord Blood Bank, Inc. (NECBB) is pleased to announce that it now processes its cord blood using the Sepax 2 system from Biosafe. Biosafe is the world leader in stem cell processing, serving stem cell banks, hospitals and research institutes alike with innovative cell processing solutions.

Sepax 2 is a fully automated, mobile, closed capability system that provides the most efficient and consistent processing of umbilical cord blood. The system involves processing of the umbilical cord blood via both its "plasma depletion" method and the "red cell reduction" method. The Sepax system provides the NECBB client with exceptional post-thaw cell viability count. This ensures that your family will have the greatest supply of high quality stem cells available should transplant become necessary. Sepax processes every cord blood unit individually, respecting its biologic specificity and unique cell characteristics.
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NECBB processes and stores lifesaving stem cells for thousands of families worldwide. Cord blood stem cells, obtained from the umbilical cord immediately following birth, are currently used to treat and cure more than 80 diseases. Successful transplants for cancer, anemia and other blood based diseases occur on a regular basis at approved transplant hospitals both domestically and internationally.

Most recently, families have begun to also bank the cord tissue itself. This tissue contains regenerative stem cells that have the potential to repair virtually any tissue in the human body. NECBB is proud to offer the processing of the cord tissue, at no additional cost, when families bank their child's cord blood at NECBB.

Via: http://www.prnewswire.com
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The Monterey County district attorney sued BioBancUSA

MONTEREY, Calif. (CN) - The Monterey County district attorney sued BioBancUSA, its founder Robert Hayner, and treasurer James Swallow, alleging violations of state Health and Safety and Business and Professions Codes. BioBancUSA offering cryogenic banking of umbilical cord blood and white blood cells.
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The state accuses BioBancUSA of engaging in false advertising by, among other things, advertising state-of-the-art umbilical cord blood and white blood cell cryogenic storage services on its website and enrolling new patients after it had ceased operations.

Despite having no license or medical training, Hayner and Swallow continued caring for the specimens in the BioArchive for nearly a year before transferring them to Family Cord, a blood bank in Southern California, the states says. It says the specimens were transferred on Aug 1, 2011.

It also violated quality control policies established by the American Association of Blood Banks, such as not having enough qualified staff and failing to maintain their specimen storage equipment, the complaint states.

The state seeks $267,500 in civil penalties and $50,000 for the costs of suit, including investigation. It also seeks a permanent injunction forcing the firm to inactivate the BioBancUSA website, and "refrain from reactivating the CordBancUSA.com web site."

Monterey County District Attorney Dean Flippo filed the complaint.

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Cord Blood Registry starts groundbreaking autism study

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Cord Blood Registry, or CBR is based in Tucson, AZ is a bank of umbilical cord stem cells harvested at birth. The cells can be used to treat blood disorders, and have shown promise in treating other issues.

"We've taken this leadership role, initiating clinical trials for cerebral palsy, for traumatic brain injury, for hearing loss and now autism. If you do the math at one in 88 kids affected with autism, we have 425,000 children stored here, we expect about one in 5,000 kids banked here in the drawers that you see behind me are impacted by the condition," said Dr. Heather Brown with CBR.

So researchers decided to do something about it. They're starting a study to see if the cells stored at CBR could help autistic children.

"We've been monitoring the research that suggests umbilical cord blood stem cells might aid in the repair of the damaged immune and nervous system," Brown said.

Brown said, potentially, the cells could help with language and behavioral issues in autistic kids and since the study is done on children who have their cord blood stored here, they'll be getting their own umbilical cord blood stem cells.

CBR is still recruiting for this study. If your child has their blood stored there and is autistic, they'd like to hear from you.

Copyright 2012 CBS 5 (Meredith Corporation). All rights reserved


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New Integrated Distribution Strategy for Cord Blood Products in Western Europe

ThermoGenesis Corp., a leading supplier of enabling technologies for the processing, storage and administration of cell therapies, announced today a new integrated distribution agreement in Europe with Concessus for its cord blood products--the AXP(R) AutoXpress(R) (AXP) System and BioArchive(R) System.

The AXP System is a proprietary family of automated devices with companion sterile blood processing disposables for harvesting cord blood stem cells in closed systems and the BioArchive System is an automated robotic device for cryopreserving and archiving cord blood stem cell units for transplant.

Under the four-year agreement, Concessus will distribute both the AXP and BioArchive in the following countries: France, Spain, Switzerland, Benelux, Liechtenstein and Nordic countries (excluding Iceland). Concessus, which has been distributing the BioArchive since 2010, is a nearly 50-year-old Lisbon-based company that has been involved in the cord blood market for more than two decades. Concessus specializes in equipment for the healthcare diagnostic laboratory and research markets, with a strong focus on key markets in Western Europe.

GE Healthcare, which had been distributing the AXP in these markets, will continue to distribute the offering in the U.S. and Canada.

Source: http://www.marketwatch.com

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Missing Link Between Stem Cells, Immune System..!

According to article in MedicalXpress, UCLA researchers have discovered a type of cell that is the "missing link" between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.

Understanding the process of normal blood formation in human adults is a crucial step in shedding light on what goes wrong during the process that results in leukemias, or cancers of the blood.

The studies were done using human bone marrow, which contains all the stem cells that produce blood during postnatal life.

The research team was "intrigued to find this particular bone marrow cell because it opens up a lot of new possibilities in terms of understanding how human immunity is produced from stem cells throughout life."

Before this study, researchers had a fairly good idea of how to find and study the blood stem cells of the bone marrow. The stem cells live forever, reproduce themselves and give rise to all the cells of the blood. In the process, the stem cells divide and produce intermediate stages of development called progenitors, which make various blood lineages like red blood cells or platelets. Crooks was most interested in the creation of the progenitors that form the entire immune system, which consists of many different cells called lymphocytes, each with a specialized function to fight infection.

Previous work had found a fairly mature type of lymphocyte progenitor with a limited ability to differentiate, but the new work describes a more primitive type of progenitor primed to produce the entire immune system,

Once the lymphoid primed progenitor had been identified, Crooks and her team studied how gene expression changed during the earliest stages of its production from stem cells.

Read more at: MedicalXpress

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Robin Roberts Prepares for her Bone Marrow Transplant

ABC's "Good Morning America" team wearing their Prayer for Protection wristbands, created in honor of Robin Roberts.
(Photo provided courtesy of Good Morning America) - Business Wire
Heraldonline.com - ABC’s “Good Morning America” host Robin Roberts prepares for her bone marrow transplant, fans can show their support by purchasing a “Prayer for Protection” wristband.

The multi-colored wristband carries Roberts’ initials (RRR) and the words “Light, Love, Power, Presence”, representing the Prayer for Protection that Roberts’ mother taught her years ago.

The wristband was designed by friends of Roberts after she received her diagnosis of myelodysplastic syndrome (MDS), a blood disorder formerly known as pre-leukemia. On June 11, 2012, Roberts announced her diagnosis on national television, and that her best hope for a cure is a bone marrow transplant from her sister, Sally-Ann. The bright spring colors of the bracelet symbolize the rebirth her bone marrow transplant will bring.

Beginning Wednesday, Aug. 29, supporters can purchase packs of five wristbands for $5 at ShopBeTheMatch.org. One hundred percent of the net proceeds from each purchase at ShopBeTheMatch.org directly support the Be The Match mission to save lives.

News of Roberts’ diagnosis triggered an outpouring of support from across the nation and around the world. Since Roberts’ announcement three months ago, more than 36,000 people have joined the Be The Match Registry, greatly exceeding Be The Match’s monthly average by more than 50%.



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Charis Ober said "Easy to Save a Life just with Cord Blood Donation"

It may not be your usual topic of conversation, but Charis Ober, founder of Save the Cord Foundation takes any chance she can to talk about umbilical cord blood.

She said that, umbilical cord blood is truly a treasure...! "Unfortunately 95% of all umbilical cord blood is thrown out as medical waste," Ober explained. "And with donated cord blood, which is called alageneic or donated cord blood, we an cure and treat over 80 deadly diseases".

Those diseases include leukemia, lymphoma, Sickle Cell Anemia, and "many of the genetic diseases such as Hurlers, Lesch-Nyhan, Krabbe Disease.”

Ober also said, "a shortage of cord blood for ethnic minorities, for diseases like Sickle Cell that shortage is critical".

Charis Ober said most people, if they have heard about cord blood, have heard they can bank it themselves for possible use by their children if they get a disease or injury in the future. And that usually comes with a cost.

Most people usually don't realize is that they can can donate that cord blood to a bank for free. Cord blood is easier to match than traditional treatments like bone marrow, and treatments are often more successful.

The process is simple, women fill out all the paperwork early on in their pregnancy, and then they receive a donation kit that they take with them to the hospital. The blood is collected from the umbilical cord and placenta about 10 minutes after delivery and banked.

Ober said it really is that easy to save a life, even for a newborn.

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